➤INTRODUCTION
The Apoptosis was first introduce a scientist known as Kerr Wyllie and other was Currie .Death of cell which usually not same as compared to Necrosis.
➤What is Apoptosis?
In simple word we can say Apoptosis is a program for cell killing.In which cell outer membrane covering brust and loss their structure.
Chromosomes material became visible.DNA break down in to short length.nucleus also break down.
➤Three Types Of Cell Death.
Apoptosis
Necrosis
Autophagy
➤Factors Lead To Cell Death.
Ultra violet radiation of sun mostly harmful rays in summer june to july monts.
Chemicals extra use in which mostly contain alcohol,tobacco and nicotine drugs.
Some virus also lead cell infection in which uncontrolled cell death and division occur.
By the attack of different disease immune system weak that not support body.
➤Significance.
Cell killing for the purpose of right growth or development stage.For e.g Tadpole to Adult conversion.
Harmful genes destroy by apoptosis.
➤DNA Damage ByApoptosis.
If DNA damage by Apoptosis than increase the productivity of p53 and p 53 lead to mutation and cause cancer.In this defect embryo not develop full immature birth may occur.
➤Some Genes Which Involve In Apoptosis.
There are some genes are involved in the process of Apoptosis.
➤p53
Their location on short arm of chromosomes number 17.Function is to regulate cell growth but if regulation is reduced by attachment of another protein MDM2,COP1.
➤p21
It present on 6 number chromosomes.
➤mdm2.